ncRNA name | mmu-miR-93 |
ncRNA Category | miRNA |
Disease name | age-related macular degeneration (AMD) |
Species | Mus musculus |
Tissues/Cell_line | RPE/choroid; human microvascular endothelial cells (HMECs) |
Methods | transfection, qPCR, Western blot |
Expression pattern | down-regulated |
Functional description | Significantly decreased expression of miR-93 was observed by qPCR analysis in CNV mice compared to untreated mice (p < 0.05). VEGF-A messenger RNA (mRNA) and protein expression were upregulated with CNV; these changes were ameliorated by restoration of miR-93 (p < 0.05). CNV was reduced after miR-93 transfection. |
PubMed ID | 27349759 |
Year | 2016 |
Title | miRNA involvement in angiogenesis in age-related macular degeneration. |
Drug-related ncRNA | NO |
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